Epstein-Barr Virus (EBV) Description
This antibody reacts with a 60 kDa latent membrane protein encoded by the BNLF1 gene of the Epstein Barr Virus (EBV). All three antibodies in this cocktail recognize distinct epitopes in the hydrophillic carboxyl region of the latent membrane protein (LMP). EBV has been implicated with Hodgkins disease, and may be involved in the pathogenesis of Hodgkins occurring in children. Other studies have shown a low incidence of EBV in B-cell type lymphomas unless patients were immunologically impaired, such as post-organ transplantation or autoimmune type diseases.
This antibody does stain EBV + Burkitts lymphomas and has shown some cross-reactivity with smooth muscle and blood vessels.
PHOTO DESC.
Cat No.
Hodgkins lymphoma stained with EBV antibody cocktail.