| ANTIBODY PHOTO | TIA-1 | |
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TIA-1 Description TIA-1 (T-cell intracytoplasmic antigen) monoclonal antibody reacts with a 15 kDa cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. The expression of TIA-1 was studied in CD30+ anaplastic large cell lymphomas (ALCL), NK-cell lymphomas and peripheral T-cell lymphomas and T-cell lymphocytosis, B-cell lymphomas and lymphoblastic leukemia, Hodgkins etc. Studies showed that 60 to 70% of anaplastic large cell lymphoma reacted with TIA-1. Studies also indicate that TIA-1 reacts with most large granular lymphocytic leukemias, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas, pulmonary angiocentric lymphomas of T-or NK-phenotype. The author concluded from TIA-1 studies that anaplastic large-cell lymphomas are cytotoxic T-or NK-cell neoplasms. All B-cell lymphomas, Hodgkins and lymphoblastic leukemias were negative for TIA-1. |
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| PHOTO DESC. | Cat No. | |
| Anaplastic large cell lymphoma stained with TIA-1 antibody. | intelliPATH FLX | IP 130 G10 |
| CONCENTRATE | CM 130 A, B, C | |
| PREDILUTE | PM 130 AA | |
| CLONE | TIA-1 | |
| DOWNLOADS | SOURCE | Mouse monoclonal |
| ISOTYPE | IgG1 | |
| ANTIGEN | TIA-1 (T-cell intracytoplasm antigen) | |
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