| ANTIBODY PHOTO | Caspase-3 (Cleaved) | |
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Caspase-3 (Cleaved) Description Apoptosis is a process, in which cells activate an intrinsic suicide mechanism that destroys themselves. The proteases that mediate this execution are called caspase (cysteinyl-aspartic acid proteases). Apoptosis has gained central importance in the study of many biological processes, including neoplasia, neurodegenerative diseases, and development. Cleaved caspase-3 detects endogenous levels of the large fragment (17/19 kDa) of activated caspase-3 resulting from cleavage adjacent to (Asp175). Activation of caspase-3 requires proteolytic processing of its inactive zymogen into actived p17 and p12 subunits. Cleavage of caspase-3 requires aspartic acid at the P1 position. This antibody does not cross react with other cleaved caspases. |
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| PHOTO DESC. | Cat No. | |
| Colon cancer stained with Caspase-3 antibody. | intelliPATH FLX | N/A |
| CONCENTRATE | CP 229 A, B, C | |
| PREDILUTE | PP 229 AA | |
| CLONE | N/A | |
| DOWNLOADS | SOURCE | Rabbit polyclonal |
| ISOTYPE | N/A | |
| ANTIGEN | Caspase-3 | |
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