| ANTIBODY PHOTO | Epiderman Growth Factor Receptor (phosphorylated) Rabbit Monoclonal | |
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Epiderman Growth Factor Receptor (phosphorylated) Rabbit Monoclonal Description Epidermal Growth Factor Receptor (EGFR) is a 170 kDa transmembrane glycoprotein receptor tyrosine kinase and is activated by EGF. This activation affects cell growth and differentiation. The carboxy terminal tyrosine residues on EGFR, Tyr1068, Tyr1148 and Tyr1173, are major sites of autophosphorylation, which occurs as the result of EGF binding. Once activated, phosphotyrosines mediate the binding of growth factor receptor-binding protein-2 (Grb2) to the EGFR. This antibody only detects EGFR phosphorylated on Tyrosine 1068 of the mature human isoform that corresponds to Y1092 from the precursor form P00533-1(p170). Over-expression of EGFR has been reported in tumors of breast, lung, colon, cervix, ovary, esophagus and endometrium. |
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| PHOTO DESC. | Cat No. | |
| Breast cancer stained with Phosphorylated EGFR antibody. | intelliPATH FLX | N/A |
| CONCENTRATE | CME 300 AK | |
| PREDILUTE | PME 300 AA | |
| CLONE | EP774Y | |
| DOWNLOADS | SOURCE | Rabbit Monoclonal |
| ISOTYPE | Rabbit IgG | |
| ANTIGEN | Epidermal Growth Factor Receptor | |
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