ALDH1a1 Rabbit Monoclonal (Aldehyde dehydrogenase1) Description
The ALHD1a1 gene encodes the major cytosolic ALDH1a1 existing in the liver and other tissues. The genetic deficiency of this isozyme has been found at a low frequency (< 10%) in both Caucasians and Asians. Studies have also shown that ALDH1a1 in normal and cancer human mammary epithelial cells with increased aldehyde
dehydrogenase activity have stem/progenitor properties. In a series of 577 breast carcinomas, expression of ALDH1a1 detected by immunostaining correlated with poor prognosis. These findings offer an important new tool for the study of normal and malignant breast stem cells and facilitate the clinical application of stem cell concepts.
PHOTO DESC.
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Colon cancer stem cells stained with ALDH1 antibody.