| ANTIBODY PHOTO | Factor XIIIa | |
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Factor XIIIa Description This is a monoclonal antibody to the A-subunit of human coagulation Factor XIII. It recognizes human Factor XIII A-chain in both reduced and non-reduced forms. It does not react with human Factor XIII B-chain or human Factor XII. Factor XIII is a betaglobulin found in plasma and is composed of two subunits. Factor XIIIa is the catalytic subunit and is a dimer of M.W. 160,000. Factor XIII is present in plasma as an alpha-2/beta-2 heterodimer (M.W. 320,000); whereas in platelets, only the alpha-2 unit exists. Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system. Factor XIIIa has also been used with CD34 to differentiate between dermatofibroma and dermatofibrosarcoma protuberans. This product replaces the polyclonal Factor XIIIa product and provides superior staining intensity and specificity. |
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| PHOTO DESC. | Cat No. | |
| Dermatofibroma stained with Factor XIIIa. | intelliPATH FLX | IP 357 G10 |
| CONCENTRATE | CM 357 AK, BK, CK | |
| PREDILUTE | PM 357 AA | |
| CLONE | E980.1 | |
| DOWNLOADS | SOURCE | Mouse monoclonal |
| ISOTYPE | IgG1 | |
| ANTIGEN | Factor XIIIa c-terminus | |
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