| ANTIBODY PHOTO | Bcl-10 | |
 |
Bcl-10 Description The Bcl-10 gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT-1) lymphoma. The protein encoded by this gene contains a capsize recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappa. This protein is found to form a complex with MALT-1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT-1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenic process that leads to the malignancy. MALT-1 lymphoma is a common low grade B-cell lymphoma comprising 7-8% of all B-cell lymphomas. It arises from a background of chronic inflammatory disease at a number of mucosal sites. MALT-1 lymphomas of the stomach are causatively linked to Helicobacter pylori (H. pylori) infection and eradication of the bacterium with antibiotics leads to long-term complete regression of the lymphoma in approximately 70% of cases. |
|
| PHOTO DESC. | Cat No. | |
| Tonsil stained with Bcl-10 antibody. | intelliPATH FLX | N/A |
| CONCENTRATE | CM 358 A, B, C | |
| PREDILUTE | PM 358 AA, H | |
| CLONE | 151 | |
| DOWNLOADS | SOURCE | Mouse Monoclonal |
| ISOTYPE | MouseIgG | |
| ANTIGEN | Bcl-10 | |
 |
||
