| ANTIBODY PHOTO | DOG1 | |
 |
DOG1 Description DOG1 (protein kinase C theta) is a cell surface protein of unknown function selectively expressed in gastrointestinal stromal tumors (GIST). DOG1 expression has been reported to be a very sensitive and specific marker for GIST in paraffin-embedded tissue. Among GIST cases with KIT mutations, DOG1 detected 11% more cases than CD117. In KIT/CD117 negative and PDGFRA-mutant GIST cases, DOG1 increased the accuracy of GIST diagnosis. This has important clinical implication because most GIST patients can benefit from imatinib mesylate (Gleevec®) treatment. As a result of its presence in most GIST tissue, DOG1 may be an additional target in the diagnosis and treatment of GIST. DOG1 immunoreactivity is seen in fewer cases of mesenchymal, epithelial tumors, seminomas and melanomas when compared with CD117. |
|
| PHOTO DESC. | Cat No. | |
| GIST stained with DOG1 antibody. | intelliPATH FLX | N/A |
| CONCENTRATE | CM 385 A, C | |
| PREDILUTE | PM 385 AA | |
| CLONE | DOG1.1 | |
| DOWNLOADS | SOURCE | Mouse monoclonal |
| ISOTYPE | IgG1/k | |
| ANTIGEN | Synthetic peptide of human DOG1 | |
 |
||
