| ANTIBODY PHOTO | Lung Adeno-2™ (TTF-1 + Napsin A) | |
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Lung Adeno-2™ (TTF-1 + Napsin A) Description TTF-1 has been the premier marker for lung adenocarcinoma. A new and promising marker, Napsin A, is expressed in type II pneumocytes and in adenocarcinomas of the lung. Studies have shown Napsin A to be more sensitive and specific than TTF-1 in lung adenocarcinomas and virtually negative in all squamous carcinomas. In other studies comparing TTF-1 and SP-A, Napsin A stained more tumor cells and a higher percentage of lung adenocarcinomas than either of these antibodies. Other studies have shown that when TTF-1 and Napsin A are used in combination, a higher sensitivity and specificity is achieved. A critical assessment is essential for correct diagnosis as patients with squamous carcinoma (SqCC) cannot receive Avastin due to a 30% mortality rate as a result of fatal hemoptysis (hemorrhaging). Therefore, when used in a panel with p63 and CK5, this unique antibody cocktail of TTF-1 and Napsin A should prove useful for immunohistochemical analysis of poorly differentiated lung adenocarcinomas versus squamous cell carcinomas in formalin-fixed paraffin-embedded tissues. |
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| PHOTO DESC. | Cat No. | |
| Lung adenocarcinoma stained with Lung Adeno-2 (TTF-1 + Napsin A) multiplex cocktail. | intelliPATH FLX | N/A |
| CONCENTRATE | N/A | |
| PREDILUTE | PPM 394 DS AA | |
| CLONE | 8G7G3/1 + NA | |
| DOWNLOADS | SOURCE | Mouse monoclonal and Rabbit polyclonal |
| ISOTYPE | IgG1 + Rabbit IgG | |
| ANTIGEN | TTF-1 + Napsin A | |
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